Synthesis and Evaluation of Anisomelic acid-like Compounds
Synthesis and Evaluation of Anisomelic acid-like Compounds
In a pioneering study, we showed that a naturally occurring compound (anisomelic acid), as well as synthetic derivatives that we have developed based on this compound, effectively degrade the HPV E6 and E7 oncoproteins, i.e., the carcinogenic proteins in the virus that are known to play a key role in promoting the devel opment of HVP-positive cancers, says cell biology professor John Eriksson Paul P, Kumar Rajendran S*, Peuhu E*, Alshatwi AA, Mohammad AA, Hietanen S, and Eriksson JE (2014): Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. Biochemical Pharmacology. 89:171–184. The in ovo chick embryo chorioallantoic membrane (CAM) assay showed that anisomelic acid inhibited the tumor growth of the cervical cancer SiHa cells. AA is revealed to hold a novel action modality based on specific targeting of the HPV oncoproteins, which restores p53-mediated growth arrest and induces apoptosis by terminating E6-mediated cIAP2 stabilization. Dealing with heartburn and stomach acid troubles is an uncomfortable condition that nearly everyone experiences from time. For some people, it's a sign of gastroesophageal reflux disease (GERD).
av bröd Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular The bicinchoninic acid assay (BCA assay), also known as the Smith assay, Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular Dynamic mode and the dynamic behavior of AA with HSA and BSA. bsa protein Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular Dynamic mode and the dynamic behavior of AA with HSA and BSA. kDa large protein Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular The bicinchoninic acid assay (BCA assay), also known as the Smith assay, after its ANISOMELIC ACID (6E,10Z,14Z)-6,14-dimethyl-3-methylidene-2-oxo-3a,4,5,8,9,12,13,15a-octahydrocyclotetradeca[b]furan-10-carboxylic acid. 59632-76-7 HPV-mediated cancers. Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The present study describes the structure-activity relationship and the evaluation of synthetic AA like Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica.
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Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Scientia Pharmaceutica, 2013. Mohammad Akbarsha.
Targeted delivery of a novel anticancer compound anisomelic
Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown. Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA Anisomelic acid, one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane-type diterpenoid, which can be synthesized chemically . Anisomelic acid has also been previously isolated from A. malabarica and A. indica and it has been shown to be cytotoxic to KB cells [5, 6]. Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells.
Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.
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Find quality suppliers and manufacturers of 59632-76-7(ANISOMELIC ACID) for price inquiry. where to buy 59632-76-7(ANISOMELIC ACID).Also offer free database of 59632 1986-01-01 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Senthil Rajendran , Didem Sen Karaman, Preethy Paul , EM Björk, M Odén, John Eriksson , Jessica Rosenholm Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Biomater. Sci., 2014 Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Scientific Reports , Mar 2020 Rajendran Senthilkumar , Yury Brusentsev , Preethy Paul , Parthiban Marimuthu , Fang Cheng , Patrik C. Eklund , John Elias Eriksson Senthilkumar R, Brusentsev Y, Paul P, Marimuthu P, Cheng F, Eklund PC & Eriksson JE (2019). Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas.
13:2002-2006. Activities (22) Anthelmintic AntiHIV EC50=2.0 ug/ml Kashiwada, Y
terpenoid compounds, including Anisomelic Acid (Arisawa et al. 1986), and 15 essential oil constituents (Yadava & Barsainya 1998). Anisomeles malabarica has been shown to possess Anisomelic Acid, as well as Anisomelolide, Malabaric Acid, 2-Acetoxymalabaric Acid, Anisomelyl Acetate and Anisomelol (Preethy et al.
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Scientia Pharmaceutica, 2013. Mohammad Akbarsha. Preethy Paul.
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Preethy Paul. Ali … WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201 Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells. 8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical cancer cells by specifically down-regulating the viral oncoproteins, E6 and E6, 9,10 which are the Anisomelic acid loading to the rod-shaped mesoporous silica particles (NR-MSP) was carried out by soaking 20 mg of NR-MSPs into different concentrations of 10 mL AA-cyclohexane solution and keeping the suspension stirring overnight at room temperature. Find quality suppliers and manufacturers of 59632-76-7(ANISOMELIC ACID) for price inquiry. where to buy 59632-76-7(ANISOMELIC ACID).Also offer free database of 59632 1986-01-01 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Senthil Rajendran , Didem Sen Karaman, Preethy Paul , EM Björk, M Odén, John Eriksson , Jessica Rosenholm Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Biomater. Sci., 2014 Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Scientific Reports , Mar 2020 Rajendran Senthilkumar , Yury Brusentsev , Preethy Paul , Parthiban Marimuthu , Fang Cheng , Patrik C. Eklund , John Elias Eriksson Senthilkumar R, Brusentsev Y, Paul P, Marimuthu P, Cheng F, Eklund PC & Eriksson JE (2019).